Redefining How We Measure Brain Disease

Resonant is unlocking new insights into neurodegenerative disease with cell type–specific cfDNA profiling from a simple blood draw. We support researchers and biopharma teams seeking quantifiable, biologically grounded endpoints for disease progression and therapeutic response.

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Our Science

Dying Neurons Leave a Molecular Trace. We Capture It.

Resonant analyzes neuron- and glia-derived cell-free DNA (cfDNA) in the blood to reveal which brain cell types are undergoing degeneration. By resolving these signals to specific cell types—including cortical, dopaminergic, and motor neurons, as well as astrocytes, microglia, and Schwann cells—our assay provides a minimally invasive, systems-level view of neurodegeneration in motion.

This research-use-only (RUO) platform enables scientists to study disease mechanisms, detect early response signals, and advance new strategies for neuroprotective drug development.

Our mission

Earlier Answers.
Better Outcomes.

We believe patients deserve better tools to understand what’s happening in their brains—before symptoms appear and options narrow. At Resonant, we are developing technologies to enable earlier detection, deeper monitoring, and more personalized approaches to managing neurodegenerative disease. Through accessible, blood-based molecular tools, we aim to shift the timeline for intervention and improve quality of life for patients and caregivers.

our solutions

Translating Science Into Actionable Tools

Discovery Research

Identify cell-specific signatures of degeneration in Alzheimer’s, Parkinson’s, ALS, and related conditions

Therapeutic Response Tracking

Monitor CNS cell turnover in response to therapeutics and explore pharmacodynamic signals over time.

Looking ahead

A Platform Built for the
Future of Brain Health

Multi-Disease Detection

Simultaneous analysis of cfDNA signals across multiple neurodegenerative diseases to support broader research, cohort differentiation, and investigation of overlapping pathologies.

Greater Neuronal Resolution

Ongoing expansion of subtype-specific detection, including cortical projection neurons, hippocampal neurons, and Lewy body–associated dopaminergic neurons, for region- and mechanism-specific insights.

Clinical Intervention Studies

Exploration of cfDNA tools for therapeutic monitoring, patient stratification, and early intervention to support integration into routine clinical care for non-invasive neurodegeneration tracking.